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PRP Patient Instructions

Written by Renew Orthobiologics Center | Feb 24, 2025 11:00:00 PM

You've chosen to undergo a Platelet Rich Plasma (PRP) injection. Congratulations on taking this step to utilize your body's natural healing abilities to tackle your orthopedic issue! As outlined in our Regenerative Orthopedic Medicine Consumer's Guide, the ROC team is going to everything we can to optimize your outcome. But, what you do before and after the procedure also plays an important role in the success of your procedure. This blog provides pre- and post- procedure information and instructions to maximize the likelihood you achieve the results you are looking for. 

 

 

Pre-Procedure Instructions

 

Medications

  1. Several medications and supplements have anti-platelet, anti-inflammatory and/or anticoagulant properties which may negatively impact the benefit you receive from you PRP procedure. Here is a list of medications that should be discontinued prior to your PRP procedure. 
  2.  
  3. Non-steroidal anti-inflammatory (NSAIDs) should be discontinued 5 days prior to procedure e.g. ibuprofen, naproxen,

Celebrex, etc... You CAN take acetaminophen (Tylenol) if needed. 

  1.  
  2. Blood thinners (e.g. Aspirin, Plavix, Xarelto, Eliquis, Coumadin, etc.) will need to be held for a period of time around a PRP injection. Depending on the medication and the reason you are taking the medication, you may need to discuss clearance from the prescribing physician (family physician, cardiologist, hematologist, ...) to stop taking the medication. We can help  coordinate with your treating physician, letting them know how long we need you to be off the medication for your PRP injection.
  3.  

Supplements can interfere with the effectiveness of PRP. Here is the list of supplements you should discontinue one week prior to your PRP: Fish oil, Flax oil, Turmeric, Curcumin, Vitamin E and Vitamin A. 

 

NOTE: If you are having a PRP procedure that includes an intra-osseous (into the bone) injection, we will coordinate ahead of time to send a prescription pain medication to the pharmacy for you to take one hour prior to your procedure. 

 

  1. Diet

  2. Being well hydrated makes the blood draw easier for both you as the patient and our team. Make sure you hydrate well the day before as well as the day of your procedure. You should aim to have at least three 8oz glasses of water before arriving in our office on the day of your PRP. 

 

Avoid high fat content meals (e.g. fried or greasy foods) for 12 hours prior to procedure and avoid large meal 4 hours prior to procedure as fat in your bloodstream becomes remains suspended in the plasma which becomes part of the PRP.

 

Alcohol has been shown to inhibit platelet activity so should be avoided for the week before your procedure. Similarly tobacco use inhibits the body's healing response and should be discontinued in general, but at least 1 week.

 

Logistics

  1. Arrange for a friend or family member to provide transportation for you on the day of the procedure.

Post-procedure pain may interfere with your ability to drive.

 

 

 

Post-Procedure Instructions

  1.  
  2. General

  3. We recommend having someone drive you home after the procedure as post procedure discomfort may Interfere with your ability to drive safely.
  4.  

Most people will experience discomfort and swelling for the first 2 days (up to 1-2 weeks) following the procedure. This is normal and part of the healing cascade created by the platelet injection. If your PRP included an intra-osseous (into the bone) injection, you may have notable pain for the first couple days that requires prescription pain medication. 

 

  1. If you develop fever, persistent redness and swelling at the site of injection, call our office. These may be a sign of infection.
  2.  

Medication

  1. Blood thinners (e.g. Aspirin, Plavix, Coumadin, etc.) may be resumed 24 hours after the procedure.

 

  1. Avoid anti-inflammatory medications for at least 2 but preferably 6 weeks after the procedure (e.g. ibuprofen, naproxen,

Celebrex, etc.).

 

  1. You may take Extra Strength Tylenol as needed for pain OR prescribed pain medication (if provided).

 

  1. Activity

If your procedure was in the foot / ankle region, we generally recommend utilizing a walking boot for the first few days, up to 1-2 weeks depending on how you feel. 

 

For procedures performed for arthritis, we recommend limited activities of daily living for the first couple of weeks. Then, gradual increase in activity as tolerated is appropriate. 

 

If your procedure was performed to a muscle, tendon or UCL, your post-procedure course will include participation in rehabilitation exercises with a gradual progression back to full athletic activity over a 3 month time frame for optimal results. Specific activity / rehabilitation program will be discussed but generally includes an initial 6 week basic strengthening load followed by a 6 week return to sport specific activity progression. 

 

Procedure Benefit Time Frame

As previously noted, unlike a steroid injection, most people will feel worse for at least the first couple of days following a PRP injection. 

While some people will notice improved symptoms within a couple of days of their PRP, most will take a couple of week to start noticing improvement and will only appreciate approximately 80% of their improvement 6 weeks following the procedure. Maximum benefit is generally noted 3-6 months from procedure date. It is common for individuals who chose to have a combination of shockwave and PRP to not only notice overall better results that PRP alone, they also tend to notice benefit earlier. While not everyone responds to PRP, for those who do, the duration of benefit can be permanent for tendon / ligament conditions and generally 12-18+ months for arthritis. 

 

Still in the phase of research and discovery, wondering if regenerative orthopedic medicine procedures like PRP are right for you? Contact us now to see how the ROC team can help you achieve your goals!